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• #Joe cable lab upenn series#

There were no television sets then I suppose that today families gather similarly to watch TV.

On many evenings, my father, my grandfather, and his two sons-in-law gathered to play pinochle and smoke cigars. Then my grandfather built two adjacent homes for himself and my parents and their growing family. We soon moved to another rental in a two-family house in Flushing. By the time I started school, we had moved to an apartment in a row of two-story buildings across the street from the school I first attended, quite close to the Steinway piano factory. On the third floor was a small apartment for a couple who cared for the property and cleaned my father's office. On the ground floor were a drug store and tailor shop, both sources of rental income for our family. Behind the waiting room was our family apartment. My earliest memory is of my father's office and waiting room on the second floor, which are still there. I can remember patients returning years later to pay their debts. My father never sent a patient a bill or asked for payment, maybe in gratitude for his family's good fortune. in Astoria, Queens, a poor working-class area, as a graduation gift to his only son, my father, who was a dentist. He built the building at 3320 Ditmars Blvd. He was first employed as a carpenter in the growing city, but by the time I was born he was the relatively prosperous owner of a construction company. The best memories in our family say it was Czernowitz, which is now in the southwest corner of Ukraine but was then part of the Austro-Hungarian Empire at the time of his naturalization, he renounced allegiance to Franz Josef I, Emperor of Austria and Pontifical King of Hungary. I am not absolutely certain of the origin of the paternal grandfather who gave me my surname. My grandparents met in the great melting pot of immigrants, New York City. I was born in 1925, the first of three brothers whose grandparents had all emigrated in the 1890s from Eastern Europe: Belarus, Ukraine, and Lithuania. It has been a wonderful scientific journey. More recently, the laboratory has focused on natural killer cells and their roles in peripheral blood and in the pregnant uterine decidua. Twenty-five years later, the last half of which was spent in a stimulating collaboration with the late Don Wiley, our labs had isolated, crystallized, and elucidated the three-dimensional structures of these molecules and shown that their principal function was to present peptides to the immune system in initiating an immune response. I then switched fields, moving to Harvard in 1968 and beginning the study of human HLA proteins. Twenty years later, my lab had outlined the structure and biosynthesis of the peptidoglycan of bacterial cell walls and had discovered that penicillin inhibited the terminal step in its biosynthesis catalyzed by transpeptidases. With advice from colleagues, I initiated a study of how penicillin kills bacteria. At age 26, I had a fully funded, independent laboratory and did not know what to work on.

#Joe cable lab upenn series#

AbstractAfter starting out to become a physician, by a series of accidents I found myself at NIH in 1951 during its most productive growth phase.